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By J. X. Thomas Jr. Ph.D., M. W. Gerdisch (auth.), Gerd Heusch, John Ross Jr. (eds.)

ISBN-10: 3662110385

ISBN-13: 9783662110386

ISBN-10: 3662110407

ISBN-13: 9783662110409

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The membrane-spanning domains of the protein are depicted and labeled as 1 through 7 based on data reported in [14, 45]. how pathophysiologic changes lead to alterations in the structure and coupling of these membrane bound receptors. Coupling of the lXI-adrenergic receptor to intracellular events There are substantial data in the literature to indicate the IXI -adrenergic receptors are coupled to phospholipase C, resulting in cleavage of phosphatidylinositol bisphosphate (PIP2 ) to form inositol trisphosphate (IP3 ) and diacylglycerol (Fig.

Churchill Livingstone, Edinburgh, London, Melbourne and New York. 21. Culling W, Penny WJ, Lewis MJ, Middleton K, Sheridan DJ (1984) Effects of myocardial catecholamine depletion on cellular electrophysiology and arrhythmias during ischaemia and reperfusion. Cardiovasc Res 18: 675-682 22. Dart AM (1988) Influence of myocardial ischaemia on exocytotic noradrenaline release. In: Brachmann J, Schiimig A (Eds) Adrenergic System and Ventricular Arrhythmias in Myocardial Infarction. Springer Verlag, New York-Berlin-Heidelberg, pp 34-43 23.

Richardt G, Lumpp U, Haass M, Sch6mig A (1990) Propranolol inhibits nonexocytotic noradrenaline release in myocardial ischemia. Naunyn-Schmiedeberg's Arch Pharmacol 341: 50-55 99. Richardt G, Waas W, Kranzh6fer R, Cheng B, Lohse MJ, Sch6mig A (1989) Interaction between the release of adenosine and noradrenaline during sympathetic stimulation: A feed-back mechanism in rat heart. J Mol Cell Cardiol 21: 269-277 100. Richardt G, Waas W, Kranzh6fer R, Mayer E, Sch6mig A (1987) Adenosine inhibits exocytotic release of endogenous noradrenaline in the rat heart: A protective mechanism in early myocardial ischemia.

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Adrenergic Mechanisms in Myocardial Ischemia by J. X. Thomas Jr. Ph.D., M. W. Gerdisch (auth.), Gerd Heusch, John Ross Jr. (eds.)

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