By Prof. K. A. Jellinger MD (auth.), Prof. Dr. Kurt A. Jellinger, Prof. Dr. Reinhold Schmidt, Dr. Manfred Windisch (eds.)
Epidemiological reports, sleek medical, neuroimaging, neuropsychological, molecular organic, and genetic reports have significantly more desirable our wisdom approximately growing old procedures of the human mind, its sequelae, diagnostic, and healing probabilities and boundaries. as well as Alzheimer's disorder and different degenerative dementias, the effect of cerebrovascular lesions and their hazard elements within the pathogenesis of cognitive problems of the elderly are more and more said, and the popularity of light cognitive impairment as a common preliminary level of constructing dementia is changing into an more and more vital diagnostic and healing challenge. The integrated papers have been provided on the seventh foreign Symposium in Graz, Sept. 2001 and provides a well timed evaluate of the present and destiny strategies of pathogenesis, prognosis, and therapy recommendations of pathological mind getting old and dementias, early popularity of gentle cognitive impairment and destiny possiblities of prevention of dementing processes.
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Additional resources for Ageing and Dementia Current and Future Concepts
A review of the vast majority of these scales has been published by Scheltens et al. (1998). 43 CT and MRI rating of white matter changes The scale of Wahlund and co workers Most rating scales for WMC are tailored for either MRI or CT scans . , 1990). Most recently Wahlund et al. (2001) introduced such a rating scale. 77 scan pairs of CT and MRI from 4 different sites using different scanners were evaluated by 4 raters. The scale addressed extent and anatomical distribution of WMC and the authors compared the validity of MRI against CT in detecting lesions (Table 1 and 2).
Van Dijk et al. Methodological issues in comparing frequencies Imaging WML are visible on both MRI and CT images as patchy lesions in the white matter of th e centrum semi-ovale or directly adjacent to the ventricles. On MRI, WML are seen as hyperintense lesions on Proton Density, T2-weighted or FLAIR ima ges, without prominent hypodensity on Tl-weighted images. , 2001) . Fisher defined lacunar infarcts according to pathological observations as deep sharply margined focal lesions with a diameter ranging from 3 to 15 mm (Fisher, 1982) .
At Risk factors and progression of small vessel disease-related cerebral abnormalities R. Schmidt', F. Fazekas' >, C. Enzinger", S. Ropele-, P. Kapeller' >, and H. Schmidt' D epartment of Neurology, 2MR Centre, and 3 Institute of Medical Biochemistry and Medical Molecular Biology, Karl -Franzens University, Graz, Austria 1 A three year follow-up of 273 participants (mean age 60 years) of the Austrian Stroke Prevention Study provides first information on the rate and clinical predictors of progression of small vessel disease related cerebral abnormalities including white matter changes and lacunes.
Ageing and Dementia Current and Future Concepts by Prof. K. A. Jellinger MD (auth.), Prof. Dr. Kurt A. Jellinger, Prof. Dr. Reinhold Schmidt, Dr. Manfred Windisch (eds.)